› 2gaq

Solution NMR

NMR SOLUTION STRUCTURE OF THE FRB DOMAIN OF mTOR

Released:
DOI: 10.2210/pdb2gaq/pdb
PDB entry 2gaq coloured by chain, ensemble of 19 models, front view.
PDB entry 2gaq coloured by chain, ensemble of 19 models, side view.
PDB entry 2gaq coloured by chain, ensemble of 19 models, top view.
Source organism: Homo sapiens
Primary publication:
The FRB domain of mTOR: NMR solution structure and inhibitor design.
Leone M, Crowell KJ, Chen J, Jung D, Chiang GG, Sareth S, Abraham RT, Pellecchia M
Biochemistry 45 10294-302 (2006)
PMID: 16922504

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154617 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase mTOR Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 12.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P42345 (Residues: 2015-2114; Coverage: 4%)
Gene names: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
Sequence domains: FKBP12-rapamycin binding domain
Structure domains: FKBP12-rapamycin binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics energy minimization
Expression system: Escherichia coli BL21

Quick links

Citations

14 review citations

mTOR signaling: at the crossroads of plasticity, memory and disease.
Hoeffer et al. (2010)
13 more

1 mention without citation

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Chen et al. (2017)