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Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5

X-ray diffraction
1.9Å resolution
PDB entry 2g99 coloured by chain, front view.
PDB entry 2g99 coloured by chain, side view.
PDB entry 2g99 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: WD repeat-containing protein 5 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 12006.17 Å2
Buried surface area: 862.85 Å2
Dissociation area: 431.43 Å2
Dissociation energy (ΔGdiss): -0.5 kcal/mol
Dissociation entropy (TΔSdiss): 5.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158476
Assembly 2
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Assembly Name: WD repeat-containing protein 5 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 12090.01 Å2
Buried surface area: 965.71 Å2
Dissociation area: 482.85 Å2
Dissociation energy (ΔGdiss): -0.01 kcal/mol
Dissociation entropy (TΔSdiss): 5.93 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158476

Macromolecules

WD repeat-containing protein 5
Chains: A, B
Length: 308 amino acids
Theoretical weight: 33.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 27-334; Coverage: 92%)
Gene names: BIG3, WDR5
Pfam: WD domain, G-beta repeat
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
WD repeat-containing protein 5 in PDB entry 2g99, assembly 1, front view.
WD repeat-containing protein 5 in PDB entry 2g99, assembly 1, side view.
WD repeat-containing protein 5 in PDB entry 2g99, assembly 1, top view.
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Histone H3
Chains: C, D
Length: 10 amino acids
Theoretical weight: 1.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
Histone H3 in PDB entry 2g99, assembly 1, front view.
Histone H3 in PDB entry 2g99, assembly 1, side view.
Histone H3 in PDB entry 2g99, assembly 1, top view.
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