› 2g6p

X-ray diffraction
1.9Å resolution

Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with Pyridyl pyrimidine derivative

Released:
DOI: 10.2210/pdb2g6p/pdb
PDB entry 2g6p coloured by chain, front view.
PDB entry 2g6p coloured by chain, side view.
PDB entry 2g6p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases.
Hu X, Addlagatta A, Matthews BW, Liu JO
Angew Chem Int Ed Engl 45 3772-5 (2006)
PMID: 16724298

Function and Biology Details

Reaction catalysed: 
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methionine aminopeptidase 1 Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 34.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53582 (Residues: 81-384; Coverage: 79%)
Gene names: KIAA0094, METAP1
Sequence domains: Metallopeptidase family M24
Structure domains: Creatinase/methionine aminopeptidase superfamily

Ligands and Environments

5 bound ligands:
Ligand CO 3 x CO
Ligand K 1 x K
Ligand HM2 1 x HM2
Ligand EPE 1 x EPE
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 47.386Å b: 77.522Å c: 47.72Å
α: 90° β: 90.82° γ: 90°
R-values:
R R work R free
0.193 0.193 0.241
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Metallo-aminopeptidase inhibitors.
Mucha et al. (2010)
1 more

6 mentions without citation

Advances in Bacterial Methionine Aminopeptidase Inhibition.
Helgren et al. (2016)
5 more