PDB 2g6d biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Cathepsin S
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Multimeric state: monomeric

PDBe Complex ID: PDB-CPX-150575

$Monomeric assembly 1 of PDB entry 2g6d coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Cathepsin S;</li> <li class='image_legend_li'>1 copy of N-[(1S)-1-[({(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}AMINO)CARBONYL]-3-(PHENYLSULFONYL)PROPYL]MORPHOLINE-4-CARBOXAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 2g6d coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Cathepsin S;</li> <li class='image_legend_li'>1 copy of N-[(1S)-1-[({(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}AMINO)CARBONYL]-3-(PHENYLSULFONYL)PROPYL]MORPHOLINE-4-CARBOXAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 2g6d coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Cathepsin S;</li> <li class='image_legend_li'>1 copy of N-[(1S)-1-[({(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}AMINO)CARBONYL]-3-(PHENYLSULFONYL)PROPYL]MORPHOLINE-4-CARBOXAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Cathepsin S

Chain: A
Length: 217 amino acids
Theoretical weight: 24.08 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:

Canonical: P25774 (Residues: 115-331; Coverage: 69%)

Gene name: CTSS
Pfam: Papain family cysteine protease
InterPro:

Peptidase C1A, papain C-terminal
Papain-like cysteine peptidase superfamily
Papain-like cysteine endopeptidase
Peptidase C1A
Cysteine peptidase, cysteine active site
Cysteine peptidase, histidine active site
Cysteine peptidase, asparagine active site

CATH: Cysteine proteinases
SCOP: Papain-like

Cathepsin S in PDB entry 2g6d, assembly 1, front view.

Cathepsin S in PDB entry 2g6d, assembly 1, side view.

Cathepsin S in PDB entry 2g6d, assembly 1, top view.

FASTA Sequence


    >pdb|2g6d|A

LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCRKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEKGYIRMARNKGNHCGIASFPSYPEI

PDBe-KB: UniProt Coverage View: P25774

Molecule details ›

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FASTA (Protein chains A)
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Updated mmCIF file
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PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

Search similar proteins

Similar 3D structures (PDBeFold)
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BLAST P25774 (UniProt)

Protein Data Bank in Europe

Human cathepsin S mutant with vinyl sulfone inhibitor CRA-14009

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Assemblies

Assembly 1 (preferred)

Macromolecules

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PDBe › 2g6d › Structure analysis

Human cathepsin S mutant with vinyl sulfone inhibitor CRA-14009

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Assemblies

Assembly 1 (preferred)

Macromolecules

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2g6d › Structure analysis