PDBe 2g2f

X-ray diffraction
2.7Å resolution

A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 287 amino acids
Theoretical weight: 33.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00519 (Residues: 229-512; Coverage: 25%)
Gene names: ABL, ABL1, JTK7
Sequence domains: Protein tyrosine kinase
Structure domains:
ATP-Peptide Conjugate Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.19 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P21212
Unit cell:
a: 105.669Å b: 133.322Å c: 56.576Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.286
Expression systems:
  • Escherichia coli
  • Not provided