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Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring

X-ray diffraction
2.2Å resolution
PDB entry 2g21 coloured by chain, front view.
PDB entry 2g21 coloured by chain, side view.
PDB entry 2g21 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Renin
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-133565
Assembly 2
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Assembly Name: Renin
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-133565

Macromolecules

Renin
Chains: A, B
Length: 333 amino acids
Theoretical weight: 36.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00797 (Residues: 74-406; Coverage: 87%)
Gene name: REN
Pfam: Eukaryotic aspartyl protease
InterPro:
CATH: Acid Proteases
Renin in PDB entry 2g21, assembly 1, front view.
Renin in PDB entry 2g21, assembly 1, side view.
Renin in PDB entry 2g21, assembly 1, top view.
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