PDBe 2g1t

X-ray diffraction
1.8Å resolution

A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP-Peptide Conjugate Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 13 amino acids
Theoretical weight: 1.53 KDa
Source organism: Synthetic construct
Expression system: Not provided
Tyrosine-protein kinase ABL1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 287 amino acids
Theoretical weight: 33.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00519 (Residues: 229-512; Coverage: 25%)
Gene names: ABL, ABL1, JTK7
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 12.3.1
Spacegroup: P21
Unit cell:
a: 62.586Å b: 78.44Å c: 141.609Å
α: 90° β: 90.11° γ: 90°
R-values:
R R work R free
0.221 0.219 0.244
Expression systems:
  • Not provided
  • Escherichia coli