› › Structure analysis

Crystal structure of TACE in complex with IK682

X-ray diffraction
2.1Å resolution
PDB entry 2fv5 coloured by chain, front view.
PDB entry 2fv5 coloured by chain, side view.
PDB entry 2fv5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Disintegrin and metalloproteinase domain-containing protein 17
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 12569.11 Å2
Buried surface area: 1045.98 Å2
Dissociation area: 486.16 Å2
Dissociation energy (ΔGdiss): 7.78 kcal/mol
Dissociation entropy (TΔSdiss): 5.1 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-160275
Assembly 2
Download    3D Visualisation
Assembly Name: Disintegrin and metalloproteinase domain-containing protein 17
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 12321.49 Å2
Buried surface area: 1054.05 Å2
Dissociation area: 489.86 Å2
Dissociation energy (ΔGdiss): 8.22 kcal/mol
Dissociation entropy (TΔSdiss): 5.09 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-160275

Macromolecules

Disintegrin and metalloproteinase domain-containing protein 17
Chains: A, B
Length: 261 amino acids
Theoretical weight: 29.38 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P78536 (Residues: 216-475; Coverage: 32%)
Gene names: ADAM17, CSVP, TACE
Pfam: Metallo-peptidase family M12B Reprolysin-like
InterPro:
CATH: Collagenase (Catalytic Domain)
Disintegrin and metalloproteinase domain-containing protein 17 in PDB entry 2fv5, assembly 1, front view.
Disintegrin and metalloproteinase domain-containing protein 17 in PDB entry 2fv5, assembly 1, side view.
Disintegrin and metalloproteinase domain-containing protein 17 in PDB entry 2fv5, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links