Function and Biology Details
Reactions catalysed:
Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends
Elimination of sulfate, appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Heparin and heparin-sulfate lyase (preferred)
PDBe Complex ID:
PDB-CPX-111657 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Heparin and heparin-sulfate lyase
Molecule details ›
Chains: A, B
Length: 747 amino acids
Theoretical weight: 84.71 KDa
Source organism: Pedobacter heparinus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Structure domains:
Length: 747 amino acids
Theoretical weight: 84.71 KDa
Source organism: Pedobacter heparinus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
C6XZB6 (Residues: 26-772; Coverage: 100%)
Sequence domains:
Structure domains:
