PDBe 2fsz

X-ray diffraction
2.2Å resolution

A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo octamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 246 amino acids
Theoretical weight: 27.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92731 (Residues: 257-502; Coverage: 46%)
  • Best match: Q92731-3 (Residues: 257-318)
Gene names: ESR2, ESTRB, NR3A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I4
Unit cell:
a: 105.04Å b: 105.04Å c: 102.391Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.274 0.273 0.299
Expression system: Escherichia coli BL21(DE3)