Structure analysis

Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen

X-ray diffraction
3.1Å resolution
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18100 Å2
Buried surface area: 6900 Å2
Dissociation area: 1,100 Å2
Dissociation energy (ΔGdiss): 11 kcal/mol
Dissociation entropy (TΔSdiss): 8 kcal/mol
Interface energy (ΔGint): -35 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 17900 Å2
Buried surface area: 7100 Å2
Dissociation area: 1,100 Å2
Dissociation energy (ΔGdiss): 6 kcal/mol
Dissociation entropy (TΔSdiss): 8 kcal/mol
Interface energy (ΔGint): -33 kcal/mol
Symmetry number: 1

Macromolecules

Chains: E, F
Length: 14 amino acids
Theoretical weight: 1.36 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P02458 (Residues: 461-474; Coverage: 1%)
Gene name: COL2A1

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