PDB 2fq9 biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Cathepsin S
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Multimeric state: monomeric

PDBe Complex ID: PDB-CPX-150575

$Monomeric assembly 1 of PDB entry 2fq9 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Cathepsin S;</li> <li class='image_legend_li'>1 copy of N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 2fq9 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Cathepsin S;</li> <li class='image_legend_li'>1 copy of N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 2fq9 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Cathepsin S;</li> <li class='image_legend_li'>1 copy of N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Cathepsin S
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Multimeric state: monomeric

PDBe Complex ID: PDB-CPX-150575

$Monomeric assembly 2 of PDB entry 2fq9 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Cathepsin S;</li> <li class='image_legend_li'>1 copy of N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 2fq9 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Cathepsin S;</li> <li class='image_legend_li'>1 copy of N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 2fq9 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Cathepsin S;</li> <li class='image_legend_li'>1 copy of N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Cathepsin S

Chains: A, B
Length: 225 amino acids
Theoretical weight: 25.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Canonical: P25774 (Residues: 114-300, 303-331; Coverage: 69%)

Gene name: CTSS
Pfam: Papain family cysteine protease
InterPro:

Peptidase C1A, papain C-terminal
Papain-like cysteine peptidase superfamily
Papain-like cysteine endopeptidase
Peptidase C1A
Cysteine peptidase, cysteine active site
Cysteine peptidase, histidine active site
Cysteine peptidase, asparagine active site

CATH: Cysteine proteinases
SCOP: Papain-like

Cathepsin S in PDB entry 2fq9, assembly 1, front view.

Cathepsin S in PDB entry 2fq9, assembly 1, side view.

Cathepsin S in PDB entry 2fq9, assembly 1, top view.

FASTA Sequence


    >pdb|2fq9|A B

ILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEIGHHHHHH

PDBe-KB: UniProt Coverage View: P25774

Molecule details ›

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FASTA (Protein chains A, B)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

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BLAST P25774 (UniProt)

Protein Data Bank in Europe

Cathepsin S with nitrile inhibitor

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 2fq9 › Structure analysis

Cathepsin S with nitrile inhibitor

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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2fq9 › Structure analysis