› 2fp3

X-ray diffraction
2.5Å resolution

Crystal structure of the Drosophila initiator caspase Dronc

Released:
DOI: 10.2210/pdb2fp3/pdb
PDB entry 2fp3 coloured by chain, front view.
PDB entry 2fp3 coloured by chain, side view.
PDB entry 2fp3 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structure and activation mechanism of the Drosophila initiator caspase Dronc.
Yan N, Huh JR, Schirf V, Demeler B, Hay BA, Shi Y
J Biol Chem 281 8667-74 (2006)
PMID: 16446367

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195054 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase Nc subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 35.61 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9XYF4 (Residues: 136-450; Coverage: 70%)
Gene names: CG8091, Dronc, Nc
Sequence domains: Caspase domain
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1, CHESS BEAMLINE F2
Spacegroup: I4132
Unit cell:
a: 162.474Å b: 162.474Å c: 162.474Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.222 0.268
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Apoptosome: a platform for the activation of initiator caspases.
Bao et al. (2007)
5 more

1 mention without citation

Caspases from scleractinian coral show unique regulatory features.
Shrestha et al. (2020)