PDBe 2fo0

X-ray diffraction
2.27Å resolution

Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chain: A
Molecule details ›
Chain: A
Length: 495 amino acids
Theoretical weight: 56.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00519 (Residues: 38-512; Coverage: 42%)
Gene names: ABL, ABL1, JTK7
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21212
Unit cell:
a: 79.688Å b: 117.266Å c: 60.416Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.246
Expression system: Spodoptera frugiperda