› 2fej

Solution NMR

Solution structure of human p53 DNA binding domain.

Released:
DOI: 10.2210/pdb2fej/pdb
PDB entry 2fej coloured by chain, ensemble of 36 models, front view.
PDB entry 2fej coloured by chain, ensemble of 36 models, side view.
PDB entry 2fej coloured by chain, ensemble of 36 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of p53 core domain: structural basis for its instability.
Cañadillas JM, Tidow H, Freund SM, Rutherford TJ, Ang HC, Fersht AR
Proc Natl Acad Sci U S A 103 2109-14 (2006)
PMID: 16461916

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138105 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chain: A
Molecule details ›
Chain: A
Length: 204 amino acids
Theoretical weight: 23.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 94-297; Coverage: 52%)
Gene names: P53, TP53
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Structural biology of the tumor suppressor p53.
Joerger et al. (2008)
22 more

35 mentions without citation

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept.
Uversky VN. (2016)
34 more