PDBe 2fcw

X-ray diffraction
1.26Å resolution

Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP).

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Low-density lipoprotein receptor Chain: B
Molecule details ›
Chain: B
Length: 80 amino acids
Theoretical weight: 8.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01130 (Residues: 107-186; Coverage: 10%)
Gene name: LDLR
Sequence domains: Low-density lipoprotein receptor domain class A
Structure domains: Low-density Lipoprotein Receptor
Alpha-2-macroglobulin receptor-associated protein Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P30533 (Residues: 250-357; Coverage: 33%)
Gene names: A2MRAP, LRPAP1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 118.523Å b: 30.019Å c: 58.143Å
α: 90° β: 96.57° γ: 90°
R-values:
R R work R free
0.152 0.152 0.2
Expression system: Escherichia coli BL21