Function and Biology

Crystal structure of the inactive state of the Smase I, a sphingomyelinase D from Loxosceles laeta venom

Source organism: Loxosceles laeta
Biochemical function: toxin activity
Biological process: modulation of process of another organism
Cellular component: extracellular region

Sequence family

InterPro InterPro annotation
IPR017946
Domain description: PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Occurring in:
  1. Dermonecrotic toxin LlSicTox-alphaIII1i

Structure domain

CATH CATH domain
3.20.20.190
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Phosphatidylinositol (PI) phosphodiesterase
Occurring in:
  1. Dermonecrotic toxin LlSicTox-alphaIII1i
The deposited structure of PDB entry 2f9r contains 4 copies of CATH domain 3.20.20.190 (TIM Barrel) in Dermonecrotic toxin LlSicTox-alphaIII1i. Showing 1 copy in chain A.