› 2f9l

X-ray diffraction
1.55Å resolution

3D structure of inactive human Rab11b GTPase

Released:
DOI: 10.2210/pdb2f9l/pdb
PDB entry 2f9l coloured by chain, front view.
PDB entry 2f9l coloured by chain, side view.
PDB entry 2f9l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform.
Scapin SM, Carneiro FR, Alves AC, Medrano FJ, Guimarães BG, Zanchin NI
J Struct Biol 154 260-8 (2006)
PMID: 16545962

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-11B Chain: A
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15907 (Residues: 8-205; Coverage: 91%)
Gene names: RAB11B, YPT3
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P212121
Unit cell:
a: 45.79Å b: 52.218Å c: 59.351Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.238
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The potential role of Aurora kinase inhibitors in haematological malignancies.
Farag SS. (2011)
3 more

9 mentions without citation

Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology.
Wilson et al. (2014)
8 more