Structure analysis

Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680

X-ray diffraction
1.91Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule


Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 14900 Å2
Buried surface area: 900 Å2
Dissociation area: 450 Å2
Dissociation energy (ΔGdiss): -1 kcal/mol
Dissociation entropy (TΔSdiss): 5 kcal/mol
Interface energy (ΔGint): -3 kcal/mol
Symmetry number: 1


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