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Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor

Source organism: Homo sapiens
Biochemical function: exo-alpha-(2->8)-sialidase activity
Biological process: glycosphingolipid catabolic process
Cellular component: catalytic complex

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EC 3.2.1.18: Exo-alpha-sialidase

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Systematic name:
Acetylneuraminyl hydrolase
Alternative Name(s):
  • Acetylneuraminidase
  • Alpha-neuraminidase
  • N-acylneuraminate glycohydrolase
  • Neuraminidase
  • Sialidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13088
Domain description: BNR repeat-like domain
Occurring in:
  1. Sialidase-2
The deposited structure of PDB entry 2f11 contains 1 copy of Pfam domain PF13088 (BNR repeat-like domain) in Sialidase-2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR011040
Domain description: Sialidase
Occurring in:
  1. Sialidase-2
IPR036278
Domain description: Sialidase superfamily
Occurring in:
  1. Sialidase-2
IPR026856
Domain description: Sialidase family
Occurring in:
  1. Sialidase-2

Structure domain

CATH CATH domain
2.120.10.10
Class: Mainly Beta
Architecture: 6 Propeller
Topology: Neuraminidase
Homology: Neuraminidase
Occurring in:
  1. Sialidase-2
The deposited structure of PDB entry 2f11 contains 1 copy of CATH domain 2.120.10.10 (Neuraminidase) in Sialidase-2. Showing 1 copy in chain A.
SCOP SCOP annotation
50940
Class: All beta proteins
Fold: 6-bladed beta-propeller
Superfamily: Sialidases
Occurring in:
  1. Sialidase-2
The deposited structure of PDB entry 2f11 contains 1 copy of SCOP domain 50940 (Sialidases (neuraminidases)) in Sialidase-2. Showing 1 copy in chain A.

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