PDBe 2ewp

X-ray diffraction
2.3Å resolution

Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen-related receptor gamma Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 226 amino acids
Theoretical weight: 25.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62508 (Residues: 233-458; Coverage: 49%)
Gene names: ERR3, ERRG2, ESRRG, KIAA0832, NR3B3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 106.876Å b: 75.776Å c: 185.092Å
α: 90° β: 104.84° γ: 90°
R-values:
R R work R free
0.188 0.187 0.247
Expression system: Escherichia coli