PDBe 2ewa

X-ray diffraction
2.1Å resolution

Dual binding mode of pyridinylimidazole to MAP kinase p38

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 43.38 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47811 (Residues: 1-360; Coverage: 100%)
  • Best match: P47811-4 (Residues: 1-283)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 66.192Å b: 74.65Å c: 78.261Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.241 0.279
Expression system: Escherichia coli BL21(DE3)