PDBe 2euf

X-ray diffraction
3Å resolution

X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin homolog Chain: A
Molecule details ›
Chain: A
Length: 254 amino acids
Theoretical weight: 28.67 KDa
Source organism: Herpesvirus saimiri (strain 11)
Expression system: Spodoptera frugiperda
  • Canonical: Q01043 (Residues: 1-254; Coverage: 100%)
Gene names: 72, ECLF2
Sequence domains:
Structure domains: Cyclin A; domain 1
Cyclin-dependent kinase 6 Chain: B
Molecule details ›
Chain: B
Length: 308 amino acids
Theoretical weight: 35.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q00534 (Residues: 1-308; Coverage: 95%)
Gene names: CDK6, CDKN6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P6522
Unit cell:
a: 71.146Å b: 71.146Å c: 446.876Å
α: 90° β: 90° γ: 120°
R R work R free
0.233 0.229 0.306
Expression system: Spodoptera frugiperda