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The NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide

Solution NMR
PDB entry 2eu0 coloured by chain, ensemble of 20 models, front view.
PDB entry 2eu0 coloured by chain, ensemble of 20 models, side view.
PDB entry 2eu0 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase ITK/TSK and Lymphocyte cytosolic protein 2
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Multimeric state: hetero dimer
Accessible surface area: 6031.48 Å2
Buried surface area: 1213.28 Å2
Dissociation area: 417.8 Å2
Dissociation energy (ΔGdiss): 2.04 kcal/mol
Dissociation entropy (TΔSdiss): 6.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169913

Macromolecules

Tyrosine-protein kinase ITK/TSK
Chain: A
Length: 109 amino acids
Theoretical weight: 12.56 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q03526 (Residues: 238-344; Coverage: 17%)
Gene names: Emt, Itk, Tlk, Tsk
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
SCOP: SH2 domain
Tyrosine-protein kinase ITK/TSK in PDB entry 2eu0, assembly 1, front view.
Tyrosine-protein kinase ITK/TSK in PDB entry 2eu0, assembly 1, side view.
Tyrosine-protein kinase ITK/TSK in PDB entry 2eu0, assembly 1, top view.
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Lymphocyte cytosolic protein 2
Chain: B
Length: 8 amino acids
Theoretical weight: 795 Da
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q60787 (Residues: 143-148; Coverage: 1%)
Gene name: Lcp2
Lymphocyte cytosolic protein 2 in PDB entry 2eu0, assembly 1, front view.
Lymphocyte cytosolic protein 2 in PDB entry 2eu0, assembly 1, side view.
Lymphocyte cytosolic protein 2 in PDB entry 2eu0, assembly 1, top view.
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