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Identification of a new quaternary association for legume lectins.

Moreno FB, de Oliveira TM, Martil DE, Viçoti MM, Bezerra GA, Abrego JR, Cavada BS, Filgueira de Azevedo W
J Struct Biol 161 133-43 (2008)
Cited: 11 times
EuropePMC logo PMID: 18068379

Abstract

Lotus tetragonolobus lectin (LTA) is a fucose-specific legume lectin. Although several studies report a diverse combination of biological activities for LTA, little is known about the mechanisms involved in l-fucosyl oligosaccharide recognition. The crystal structure of LTA at 2.0A resolution reveals a different legume lectin tetramer. Its structure consists of a homotetramer composed of two back-to-back GS4-like dimers arranged in a new mode, resulting in a novel tetramer. The LTA N-linked carbohydrate at Asn4 and the unusual LTA dimer-dimer interaction are related to its particular mode of tetramerization. In addition, we used small angle X-ray scattering to investigate the quaternary structure of LTA in solution and to compare it to the crystalline structure. Although the crystal structure of LTA has revealed a conserved metal-binding site, its l-fucose-binding site presents some punctual differences. Our investigation of the new tetramer of LTA and its fucose-binding site is essential for further studies related to cross-linking between LTA and complex divalent l-fucosyl carbohydrates.

Reviews - 2eig mentioned but not cited (1)

  1. Research advances and prospects of legume lectins. Katoch R, Tripathi A. J Biosci 46 104 (2021)

Articles - 2eig mentioned but not cited (2)

  1. A cucumber mosaic virus based expression system for the production of porcine circovirus specific vaccines. Gellért A, Salánki K, Tombácz K, Tuboly T, Balázs E. PLoS ONE 7 e52688 (2012)
  2. Crystal structure of the legume lectin-like domain of an ERGIC-53-like protein from Entamoeba histolytica. Khan F, Suguna K. Acta Crystallogr F Struct Biol Commun 75 197-204 (2019)


Reviews citing this publication (1)

  1. Plant lectins: the ties that bind in root symbiosis and plant defense. De Hoff PL, Brill LM, Hirsch AM. Mol. Genet. Genomics 282 1-15 (2009)

Articles citing this publication (7)

  1. Larvicidal activity of lectins from Myracrodruon urundeuva on Aedes aegypti. Sá RA, Santos ND, da Silva CS, Napoleão TH, Gomes FS, Cavada BS, Coelho LC, Navarro DM, Bieber LW, Paiva PM. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 149 300-306 (2009)
  2. Tumor biomarker glycoproteins in the seminal plasma of healthy human males are endogenous ligands for DC-SIGN. Clark GF, Grassi P, Pang PC, Panico M, Lafrenz D, Drobnis EZ, Baldwin MR, Morris HR, Haslam SM, Schedin-Weiss S, Sun W, Dell A. Mol. Cell Proteomics 11 M111.008730 (2012)
  3. The Arabidopsis AtLEC gene encoding a lectin-like protein is up-regulated by multiple stimuli including developmental signal, wounding, jasmonate, ethylene, and chitin elicitor. Lyou SH, Park HJ, Jung C, Sohn HB, Lee G, Kim CH, Kim M, Choi YD, Cheong JJ. Mol. Cells 27 75-81 (2009)
  4. Functional correlation of bacterial LuxS with their quaternary associations: interface analysis of the structure networks. Bhattacharyya M, Vishveshwara S. BMC Struct. Biol. 9 8 (2009)
  5. Structural-functional insights and studies on saccharide binding of Sophora japonica seed lectin. Yadav P, Shahane G, Ramasamy S, Sengupta D, Gaikwad S. Int. J. Biol. Macromol. 91 75-84 (2016)
  6. Camptosemin, a tetrameric lectin of Camptosema ellipticum: structural and functional analysis. Batista FA, Goto LS, Garcia W, de Moraes DI, de Oliveira Neto M, Polikarpov I, Cominetti MR, Selistre-de-Araújo HS, Beltramini LM, Araújo AP. Eur. Biophys. J. 39 1193-1205 (2010)
  7. Fucose as a nutrient ligand for Dikarya and a building block of early diverging lineages. Orłowska M, Barua D, Piłsyk S, Muszewska A. IMA Fungus 14 17 (2023)


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