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Crystal structure of mutated EGFR kinase domain (G719S)

X-ray diffraction
2.5Å resolution
PDB entry 2eb2 coloured by chain, front view.
PDB entry 2eb2 coloured by chain, side view.
PDB entry 2eb2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Epidermal growth factor receptor
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Multimeric state: homo dimer
Accessible surface area: 28606.58 Å2
Buried surface area: 2010.92 Å2
Dissociation area: 1,005.46 Å2
Dissociation energy (ΔGdiss): 6.93 kcal/mol
Dissociation entropy (TΔSdiss): 13.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132701

Macromolecules

Epidermal growth factor receptor
Chain: A
Length: 334 amino acids
Theoretical weight: 38.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 695-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Epidermal growth factor receptor in PDB entry 2eb2, assembly 1, front view.
Epidermal growth factor receptor in PDB entry 2eb2, assembly 1, side view.
Epidermal growth factor receptor in PDB entry 2eb2, assembly 1, top view.
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