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Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase)

Source organism: Homo sapiens
Biochemical function: orotidine-5'-phosphate decarboxylase activity
Biological process: 'de novo' UMP biosynthetic process
Cellular component: not assigned

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EC 4.1.1.23: Orotidine-5'-phosphate decarboxylase

Reaction catalysed:
Orotidine 5'-phosphate = UMP + CO(2)
Systematic name:
Orotidine-5'-phosphate carboxy-lyase (UMP-forming)
Alternative Name(s):
  • ODCase
  • OMP decarboxylase
  • OMP-DC
  • OMPdcase
  • Orotate decarboxylase
  • Orotate monophosphate decarboxylase
  • Orotic decarboxylase
  • Orotidine 5'-phosphate decarboxylase
  • Orotidine monophosphate decarboxylase
  • Orotidine phosphate decarboxylase
  • Orotidine-5'-monophosphate decarboxylase
  • Orotidine-5'-phosphate carboxy-lyase
  • Orotidylic acid decarboxylase
  • Orotidylic decarboxylase
  • Orotodylate decarboxylase
  • UMP synthase
  • Uridine 5'-monophosphate synthase

EC 2.4.2.10: Orotate phosphoribosyltransferase

Reaction catalysed:
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
Systematic name:
Orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase
Alternative Name(s):
  • OPRT
  • OPRTase
  • Orotate phosphoribosyl pyrophosphate transferase
  • Orotic acid phosphoribosyltransferase
  • Orotidine 5'-monophosphate pyrophosphorylase
  • Orotidine monophosphate pyrophosphorylase
  • Orotidine phosphoribosyltransferase
  • Orotidine-5'-phosphate diphosphorylase
  • Orotidine-5'-phosphate pyrophosphorylase
  • Orotidylate phosphoribosyltransferase
  • Orotidylate pyrophosphorylase
  • Orotidylic acid phosphorylase
  • Orotidylic acid pyrophosphorylase
  • Orotidylic phosphorylase
  • Orotidylic pyrophosphorylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00215
Domain description: Orotidine 5'-phosphate decarboxylase / HUMPS family
Occurring in:
  1. Uridine 5'-monophosphate synthase
The deposited structure of PDB entry 2eaw contains 2 copies of Pfam domain PF00215 (Orotidine 5'-phosphate decarboxylase / HUMPS family) in Uridine 5'-monophosphate synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001754
Domain description: Orotidine 5'-phosphate decarboxylase domain
Occurring in:
  1. Uridine 5'-monophosphate synthase
IPR018089
Domain description: Orotidine 5'-phosphate decarboxylase, active site
Occurring in:
  1. Uridine 5'-monophosphate synthase
IPR014732
Domain description: Orotidine 5'-phosphate decarboxylase
Occurring in:
  1. Uridine 5'-monophosphate synthase
IPR011060
Domain description: Ribulose-phosphate binding barrel
Occurring in:
  1. Uridine 5'-monophosphate synthase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Uridine 5'-monophosphate synthase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Uridine 5'-monophosphate synthase
The deposited structure of PDB entry 2eaw contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in Uridine 5'-monophosphate synthase. Showing 1 copy in chain A.

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