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Structure of h-CHK1 complexed with A859017

X-ray diffraction
2Å resolution
PDB entry 2e9v coloured by chain, front view.
PDB entry 2e9v coloured by chain, side view.
PDB entry 2e9v coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase Chk1
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Multimeric state: monomeric
Accessible surface area: 13693.71 Å2
Buried surface area: 877.52 Å2
Dissociation area: 438.76 Å2
Dissociation energy (ΔGdiss): -0.56 kcal/mol
Dissociation entropy (TΔSdiss): 5.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127093
Assembly 2
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Assembly Name: Serine/threonine-protein kinase Chk1
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Multimeric state: monomeric
Accessible surface area: 13728.55 Å2
Buried surface area: 875.3 Å2
Dissociation area: 437.65 Å2
Dissociation energy (ΔGdiss): -0.65 kcal/mol
Dissociation entropy (TΔSdiss): 5.38 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127093

Macromolecules

Serine/threonine-protein kinase Chk1
Chains: A, B
Length: 268 amino acids
Theoretical weight: 30.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14757 (Residues: 2-269; Coverage: 56%)
Gene names: CHEK1, CHK1
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Serine/threonine-protein kinase Chk1 in PDB entry 2e9v, assembly 1, front view.
Serine/threonine-protein kinase Chk1 in PDB entry 2e9v, assembly 1, side view.
Serine/threonine-protein kinase Chk1 in PDB entry 2e9v, assembly 1, top view.
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