PDBe 2e9v

X-ray diffraction
2Å resolution

Structure of h-CHK1 complexed with A859017

Released:
Source organism: Homo sapiens
Entry author: Park C

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Chk1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 268 amino acids
Theoretical weight: 30.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14757 (Residues: 2-269; Coverage: 56%)
Gene names: CHEK1, CHK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P1
Unit cell:
a: 45.883Å b: 56.783Å c: 64.595Å
α: 92.83° β: 104.39° γ: 113.86°
R-values:
R R work R free
0.279 0.257 0.333
Expression system: Escherichia coli