› 2e9u

X-ray diffraction
2Å resolution

Structure of h-CHK1 complexed with A780125

Released:
DOI: 10.2210/pdb2e9u/pdb
PDB entry 2e9u coloured by chain, front view.
PDB entry 2e9u coloured by chain, side view.
PDB entry 2e9u coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Park C

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127093 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Chk1 Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 31.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14757 (Residues: 2-270; Coverage: 57%)
Gene names: CHEK1, CHK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand A25 1 x A25
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 45.075Å b: 65.82Å c: 57.945Å
α: 90° β: 94.37° γ: 90°
R-values:
R R work R free
0.242 0.227 0.277
Expression system: Escherichia coli

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