Structure analysis

TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity

X-ray diffraction
1.8Å resolution
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo trimer
Accessible surface area: 17700 Å2
Buried surface area: 6300 Å2
Dissociation area: 3,200 Å2
Dissociation energy (ΔGdiss): 26 kcal/mol
Dissociation entropy (TΔSdiss): 25 kcal/mol
Interface energy (ΔGint): -35 kcal/mol
Symmetry number: 3

Macromolecules

Chains: A, B, C
Length: 157 amino acids
Theoretical weight: 17.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01375 (Residues: 77-233; Coverage: 67%)
Gene names: TNF, TNFA, TNFSF2
Pfam: TNF(Tumour Necrosis Factor) family
InterPro:
CATH: Jelly Rolls

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