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Crystal structure of C/EBPbeta Bzip homodimer K269A mutant bound to A High Affinity DNA fragment

X-ray diffraction
2.1Å resolution
PDB entry 2e43 coloured by chain, front view.
PDB entry 2e43 coloured by chain, side view.
PDB entry 2e43 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: bZIP transcription factor complex, CEBPB-CEBPB and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 14231.59 Å2
Buried surface area: 5924.0 Å2
Dissociation area: 1,331.72 Å2
Dissociation energy (ΔGdiss): 18.23 kcal/mol
Dissociation entropy (TΔSdiss): 11.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115201

Macromolecules

CCAAT/enhancer-binding protein beta
Chains: A, B
Length: 78 amino acids
Theoretical weight: 9.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P17676 (Residues: 259-336; Coverage: 23%)
Gene names: CEBPB, PP9092, TCF5
Pfam: Basic region leucine zipper
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Leucine zipper domain
CCAAT/enhancer-binding protein beta in PDB entry 2e43, assembly 1, front view.
CCAAT/enhancer-binding protein beta in PDB entry 2e43, assembly 1, side view.
CCAAT/enhancer-binding protein beta in PDB entry 2e43, assembly 1, top view.
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DNA chain C
Name: DNA (5'-D(P*DTP*DAP*DGP*DGP*DAP*DTP*DTP*DGP*DCP*DGP*DCP*DAP*DAP*DTP*DAP*DT)-3')
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 16 nucleotides
Theoretical weight: 4.94 KDa
DNA (5'-D(P*DTP*DAP*DGP*DGP*DAP*DTP*DTP*DGP*DCP*DGP*DCP*DAP*DAP*DTP*DAP*DT)-3') in PDB entry 2e43, assembly 1, front view.
DNA (5'-D(P*DTP*DAP*DGP*DGP*DAP*DTP*DTP*DGP*DCP*DGP*DCP*DAP*DAP*DTP*DAP*DT)-3') in PDB entry 2e43, assembly 1, side view.
DNA (5'-D(P*DTP*DAP*DGP*DGP*DAP*DTP*DTP*DGP*DCP*DGP*DCP*DAP*DAP*DTP*DAP*DT)-3') in PDB entry 2e43, assembly 1, top view.
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DNA chain D
Name: DNA (5'-D(P*DAP*DAP*DTP*DAP*DTP*DTP*DGP*DCP*DGP*DCP*DAP*DAP*DTP*DCP*DCP*DT)-3')
Representative chains: D
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 16 nucleotides
Theoretical weight: 4.86 KDa
DNA (5'-D(P*DAP*DAP*DTP*DAP*DTP*DTP*DGP*DCP*DGP*DCP*DAP*DAP*DTP*DCP*DCP*DT)-3') in PDB entry 2e43, assembly 1, front view.
DNA (5'-D(P*DAP*DAP*DTP*DAP*DTP*DTP*DGP*DCP*DGP*DCP*DAP*DAP*DTP*DCP*DCP*DT)-3') in PDB entry 2e43, assembly 1, side view.
DNA (5'-D(P*DAP*DAP*DTP*DAP*DTP*DTP*DGP*DCP*DGP*DCP*DAP*DAP*DTP*DCP*DCP*DT)-3') in PDB entry 2e43, assembly 1, top view.
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