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Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase

Source organisms:
Biochemical function: lyase activity
Biological process: defense response to Gram-positive bacterium
Cellular component: extracellular region

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EC 4.6.1.18: Pancreatic ribonuclease

Reaction catalysed:
(1a) an (RNA) containing cytidine = an (RNA)-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
Systematic name:
RNA lyase ((RNA)-3'-cytidine/uridine-3'-phosphate and 5'-hydroxy-ribonucleotide-3'-(RNA) producing)
Alternative Name(s):
  • Alkaline ribonuclease
  • Ceratitis capitata alkaline ribonuclease
  • Endoribonuclease I
  • Gene S glycoproteins
  • Gene S locus-specific glycoproteins
  • Pancreatic RNase
  • RNase
  • RNase A
  • RNase I
  • Ribonuclease
  • Ribonuclease I
  • Ribonucleate 3'-pyrimidino-oligonucleotidohydrolase
  • Ribonucleic phosphatase
  • S-genotype-asssocd. glycoproteins
  • SLSG glycoproteins

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00074
Domain description: Pancreatic ribonuclease
Occurring in:
  1. Ribonuclease pancreatic
The deposited structure of PDB entry 2e33 contains 1 copy of Pfam domain PF00074 (Pancreatic ribonuclease) in Ribonuclease pancreatic. Showing 1 copy in chain B.

PF04300
Domain description: F-box associated region
Occurring in:
  1. F-box only protein 2
The deposited structure of PDB entry 2e33 contains 1 copy of Pfam domain PF04300 (F-box associated region) in F-box only protein 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001427
Domain description: Pancreatic ribonuclease
Occurring in:
  1. Ribonuclease pancreatic
IPR007397
Domain description: F-box associated (FBA) domain
Occurring in:
  1. F-box only protein 2
IPR036816
Domain description: Ribonuclease A-like domain superfamily
Occurring in:
  1. Ribonuclease pancreatic
IPR023412
Domain description: Ribonuclease A-domain
Occurring in:
  1. Ribonuclease pancreatic
IPR023411
Domain description: Ribonuclease A, active site
Occurring in:
  1. Ribonuclease pancreatic
IPR008979
Domain description: Galactose-binding-like domain superfamily
Occurring in:
  1. F-box only protein 2
IPR039752
Domain description: F-box only protein
Occurring in:
  1. F-box only protein 2

Structure domains

CATH CATH domains
3.10.130.10
Class: Alpha Beta
Architecture: Roll
Topology: P-30 Protein
Homology: Ribonuclease A-like domain
Occurring in:
  1. Ribonuclease pancreatic
The deposited structure of PDB entry 2e33 contains 1 copy of CATH domain 3.10.130.10 (P-30 Protein) in Ribonuclease pancreatic. Showing 1 copy in chain B.
2.60.120.260
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Galactose-binding domain-like
Occurring in:
  1. F-box only protein 2
The deposited structure of PDB entry 2e33 contains 1 copy of CATH domain 2.60.120.260 (Jelly Rolls) in F-box only protein 2. Showing 1 copy in chain A.
SCOP SCOP annotations
54077
Class: Alpha and beta proteins (a+b)
Fold: RNase A-like
Superfamily: RNase A-like
Occurring in:
  1. Ribonuclease pancreatic
The deposited structure of PDB entry 2e33 contains 1 copy of SCOP domain 54077 (Ribonuclease A-like) in Ribonuclease pancreatic. Showing 1 copy in chain B.
101585
Class: All beta proteins
Fold: Galactose-binding domain-like
Superfamily: Galactose-binding domain-like
Occurring in:
  1. F-box only protein 2
The deposited structure of PDB entry 2e33 contains 1 copy of SCOP domain 101585 (F-box associated region, FBA) in F-box only protein 2. Showing 1 copy in chain A.

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