PDBe 2e2b

X-ray diffraction
2.2Å resolution

Crystal structure of the c-Abl kinase domain in complex with INNO-406

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 293 amino acids
Theoretical weight: 33.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00519 (Residues: 229-515; Coverage: 25%)
Gene names: ABL, ABL1, JTK7
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32B2
Spacegroup: F222
Unit cell:
a: 110.82Å b: 147.58Å c: 152.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.236 0.27
Expression system: Spodoptera frugiperda