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Structure of mutant tryptophan synthase alpha-subunit (E244A) from a hyperthermophile, Pyrococcus furiosus

Source organism: Pyrococcus furiosus
Biochemical function: lyase activity
Biological process: tryptophan metabolic process
Cellular component: cytosol

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EC 4.2.1.20: Tryptophan synthase

Reaction catalysed:
(1a) 1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
Systematic name:
L-serine hydro-lyase (adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming)
Alternative Name(s):
  • Indoleglycerol phosphate aldolase
  • L-serine hydro-lyase (adding indoleglycerol-phosphate)
  • L-tryptophan synthetase
  • Tryptophan desmolase
  • Tryptophan synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00290
Domain description: Tryptophan synthase alpha chain
Occurring in:
  1. Tryptophan synthase alpha chain
The deposited structure of PDB entry 2dzw contains 2 copies of Pfam domain PF00290 (Tryptophan synthase alpha chain) in Tryptophan synthase alpha chain. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002028
Domain description: Tryptophan synthase, alpha chain
Occurring in:
  1. Tryptophan synthase alpha chain
IPR018204
Domain description: Tryptophan synthase, alpha chain, active site
Occurring in:
  1. Tryptophan synthase alpha chain
IPR011060
Domain description: Ribulose-phosphate binding barrel
Occurring in:
  1. Tryptophan synthase alpha chain
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Tryptophan synthase alpha chain

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Tryptophan synthase alpha chain
The deposited structure of PDB entry 2dzw contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in Tryptophan synthase alpha chain. Showing 1 copy in chain B.

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