PDBe 2dyl

X-ray diffraction
2.45Å resolution

Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)

Released:
Source organism: Homo sapiens
Entry authors: Kukimoto-Niino M, Takagi T, Kaminishi T, Uchikubo-Kamo T, Terada T, Matsuzaki O, Shirouzu M, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity mitogen-activated protein kinase kinase 7 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 35.76 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14733 (Residues: 101-405; Coverage: 73%)
  • Best match: O14733-2 (Residues: 150-448)
Gene names: JNKK2, MAP2K7, MEK7, MKK7, PRKMK7, SKK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P212121
Unit cell:
a: 61.552Å b: 69.635Å c: 84.035Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.283
Expression system: Not provided