PDBe 2dwb

X-ray diffraction
2.5Å resolution

Aurora-A kinase complexed with AMPPNP

Released:
Source organism: Homo sapiens
Entry authors: Kukimoto-Niino M, Murayama K, Shirouzu S, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 33.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14965 (Residues: 122-403; Coverage: 70%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P6122
Unit cell:
a: 81.473Å b: 81.473Å c: 174.183Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.227 0.275
Expression system: Not provided