PDBe 2duv

X-ray diffraction
2.2Å resolution

Structure of CDK2 with a 3-hydroxychromones

Released:
Source organism: Homo sapiens
Primary publication:
3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
Bioorg. Med. Chem. Lett. 17 1284-7 (2007)
PMID: 17178224

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE
Spacegroup: P212121
Unit cell:
a: 53.629Å b: 71.389Å c: 72.061Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.264 0.31
Expression system: Spodoptera frugiperda