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Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins

Source organism: Homo sapiens
Biochemical function: growth factor activity
Biological process: not assigned
Cellular component: extracellular region

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00049
Domain description: Insulin/IGF/Relaxin family
Occurring in:
  1. Insulin-like growth factor I
The deposited structure of PDB entry 2dsp contains 1 copy of Pfam domain PF00049 (Insulin/IGF/Relaxin family) in Insulin-like growth factor I. Showing 1 copy in chain B [auth I].

PF00219
Domain description: Insulin-like growth factor binding protein
Occurring in:
  1. Insulin-like growth factor-binding protein 4
The deposited structure of PDB entry 2dsp contains 1 copy of Pfam domain PF00219 (Insulin-like growth factor binding protein) in Insulin-like growth factor-binding protein 4. Showing 1 copy in chain A [auth B].

InterPro InterPro annotations
IPR022350
Domain description: Insulin-like growth factor
Occurring in:
  1. Insulin-like growth factor I
IPR016179
Domain description: Insulin-like
Occurring in:
  1. Insulin-like growth factor I
IPR000867
Domain description: Insulin-like growth factor-binding protein, IGFBP
Occurring in:
  1. Insulin-like growth factor-binding protein 4
IPR022341
Domain description: Insulin-like growth factor I
Occurring in:
  1. Insulin-like growth factor I
IPR022352
Domain description: Insulin family
Occurring in:
  1. Insulin-like growth factor I
IPR022321
Domain description: Insulin-like growth factor-binding protein family 1-6, chordata
Occurring in:
  1. Insulin-like growth factor-binding protein 4
IPR022353
Domain description: Insulin, conserved site
Occurring in:
  1. Insulin-like growth factor I
IPR036438
Domain description: Insulin-like superfamily
Occurring in:
  1. Insulin-like growth factor I
IPR017891
Domain description: Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
Occurring in:
  1. Insulin-like growth factor-binding protein 4
IPR009030
Domain description: Growth factor receptor cysteine-rich domain superfamily
Occurring in:
  1. Insulin-like growth factor-binding protein 4

Structure domains

CATH CATH domains
1.10.100.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Insulin-like, subunit E
Homology: Insulin-like
Occurring in:
  1. Insulin-like growth factor I
The deposited structure of PDB entry 2dsp contains 1 copy of CATH domain 1.10.100.10 (Insulin-like, subunit E) in Insulin-like growth factor I. Showing 1 copy in chain B [auth I].
4.10.40.20
Class: Few Secondary Structures
Architecture: Irregular
Topology: Omega-AgatoxinV
Homology: Omega-AgatoxinV
Occurring in:
  1. Insulin-like growth factor-binding protein 4
The deposited structure of PDB entry 2dsp contains 1 copy of CATH domain 4.10.40.20 (Omega-AgatoxinV) in Insulin-like growth factor-binding protein 4. Showing 1 copy in chain A [auth B].
SCOP SCOP annotations
56995
Class: Small proteins
Fold: Insulin-like
Superfamily: Insulin-like
Occurring in:
  1. Insulin-like growth factor I
The deposited structure of PDB entry 2dsp contains 1 copy of SCOP domain 56995 (Insulin-like) in Insulin-like growth factor I. Showing 1 copy in chain B [auth I].
57185
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: Growth factor receptor domain
Occurring in:
  1. Insulin-like growth factor-binding protein 4
The deposited structure of PDB entry 2dsp contains 1 copy of SCOP domain 57185 (Growth factor receptor domain) in Insulin-like growth factor-binding protein 4. Showing 1 copy in chain A [auth B].

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