PDBe 2drp

X-ray diffraction
2.8Å resolution

THE CRYSTAL STRUCTURE OF A TWO ZINC-FINGER PEPTIDE REVEALS AN EXTENSION TO THE RULES FOR ZINC-FINGER/DNA RECOGNITION

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Protein tramtrack, beta isoform Chains: A, D
Molecule details ›
Chains: A, D
Length: 66 amino acids
Theoretical weight: 8.04 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: P17789 (Residues: 501-563; Coverage: 10%)
Gene names: CG1856, FTZ-F2, ttk
Sequence domains: Zinc finger, C2H2 type
Structure domains: Classic Zinc Finger
DNA (5'-D(*CP*TP*AP*AP*TP*AP*AP*GP*GP*AP*TP*AP*AP*CP*GP*TP*C P*CP*G)-3') Chains: B, E
Molecule details ›
Chains: B, E
Length: 19 nucleotides
Theoretical weight: 5.84 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*TP*CP*GP*GP*AP*CP*GP*TP*TP*AP*TP*CP*CP*TP*TP*AP*T P*TP*A)-3') Chains: C, F
Molecule details ›
Chains: C, F
Length: 19 nucleotides
Theoretical weight: 5.79 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 60.7Å b: 64.6Å c: 117.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.193 not available
Expression systems:
  • Escherichia coli
  • Not provided