PDBe 2dq7

X-ray diffraction
2.8Å resolution

Crystal Structure of Fyn kinase domain complexed with staurosporine

Released:
Source organism: Homo sapiens
Primary publication:
Structure of human Fyn kinase domain complexed with staurosporine.
Biochem. Biophys. Res. Commun. 346 840-4 (2006)
PMID: 16782058

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fyn Chain: X
Molecule details ›
Chain: X
Length: 283 amino acids
Theoretical weight: 32.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06241 (Residues: 261-537; Coverage: 52%)
Gene name: FYN
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P3221
Unit cell:
a: 52.962Å b: 52.962Å c: 210.989Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 0.255 0.281
Expression system: Spodoptera frugiperda