PDBe 2dm0

Solution NMR

Solution structure of the SH2 domain of human Tyrosine-protein kinase TXK

Released:
Source organism: Homo sapiens
Entry authors: Endo H, Hayashi F, Yoshida M, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase TXK Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.2 KDa
Source organism: Homo sapiens
Expression system: Cell free synthesis
UniProt:
  • Canonical: P42681 (Residues: 140-251; Coverage: 21%)
Gene names: PTK4, RLK, TXK
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Cell free synthesis