PDBe 2dfp

X-ray diffraction
2.3Å resolution

X-RAY STRUCTURE OF AGED DI-ISOPROPYL-PHOSPHORO-FLUORIDATE (DFP) BOUND TO ACETYLCHOLINESTERASE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 534 amino acids
Theoretical weight: 60.57 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P04058 (Residues: 23-556; Coverage: 95%)
Gene name: ache
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P3121
Unit cell:
a: 112.636Å b: 112.636Å c: 136.881Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.186 0.228