Function and Biology

Crystal structure of the CDC42-Collybistin II complex

Source organisms:
Biochemical function: GTP binding
Biological process: positive regulation of MAPK cascade
Cellular component: Golgi membrane

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00071
Domain description: Ras family
Occurring in:
  1. Cell division control protein 42 homolog
1 copy of Pfam domain PF00071 (Ras family) in Cell division control protein 42 homolog in PDB 2dfk.

PF00621
Domain description: RhoGEF domain
Occurring in:
  1. Rho guanine nucleotide exchange factor 9
1 copy of Pfam domain PF00621 (RhoGEF domain) in Rho guanine nucleotide exchange factor 9 in PDB 2dfk.

PF00169
Domain description: PH domain
Occurring in:
  1. Rho guanine nucleotide exchange factor 9
1 copy of Pfam domain PF00169 (PH domain) in Rho guanine nucleotide exchange factor 9 in PDB 2dfk.

InterPro InterPro annotations
IPR000219
Domain description: Dbl homology (DH) domain
Occurring in:
  1. Rho guanine nucleotide exchange factor 9
IPR001849
Domain description: Pleckstrin homology domain
Occurring in:
  1. Rho guanine nucleotide exchange factor 9
IPR035899
Domain description: Dbl homology (DH) domain superfamily
Occurring in:
  1. Rho guanine nucleotide exchange factor 9
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Rho guanine nucleotide exchange factor 9
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. Cell division control protein 42 homolog
IPR003578
Domain description: Small GTPase superfamily, Rho type
Occurring in:
  1. Cell division control protein 42 homolog
IPR001806
Domain description: Small GTPase superfamily
Occurring in:
  1. Cell division control protein 42 homolog
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Cell division control protein 42 homolog

Structure domains

CATH CATH domains
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Rho guanine nucleotide exchange factor 9
1 copy of CATH domain 2.30.29.30 (PH-domain like) in Rho guanine nucleotide exchange factor 9 in PDB 2dfk.
1.20.900.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Dbl Homology Domain; Chain A
Homology: DBL homology domain (DH-domain)
Occurring in:
  1. Rho guanine nucleotide exchange factor 9
1 copy of CATH domain 1.20.900.10 (Dbl Homology Domain; Chain A) in Rho guanine nucleotide exchange factor 9 in PDB 2dfk.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Cell division control protein 42 homolog
1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Cell division control protein 42 homolog in PDB 2dfk.
SCOP SCOP annotations
52592
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Cell division control protein 42 homolog
1 copy of SCOP domain 52592 (G proteins) in Cell division control protein 42 homolog in PDB 2dfk.
50730
Class: All beta proteins
Fold: PH domain-like barrel
Superfamily: PH domain-like
Occurring in:
  1. Rho guanine nucleotide exchange factor 9
1 copy of SCOP domain 50730 (Pleckstrin-homology domain (PH domain)) in Rho guanine nucleotide exchange factor 9 in PDB 2dfk.
48066
Class: All alpha proteins
Fold: DBL homology domain (DH-domain)
Superfamily: DBL homology domain (DH-domain)
Occurring in:
  1. Rho guanine nucleotide exchange factor 9
1 copy of SCOP domain 48066 (DBL homology domain (DH-domain)) in Rho guanine nucleotide exchange factor 9 in PDB 2dfk.