Structure analysis

Crystal structure of the CDC42-Collybistin II complex

X-ray diffraction
2.15Å resolution
Source organisms:
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 29200 Å2
Buried surface area: 4000 Å2
Dissociation area: 1,500 Å2
Dissociation energy (ΔGdiss): 15 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -40 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 27100 Å2
Buried surface area: 3900 Å2
Dissociation area: 1,700 Å2
Dissociation energy (ΔGdiss): 12 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -37 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: hetero tetramer
Accessible surface area: 53200 Å2
Buried surface area: 10900 Å2
Dissociation area: 1,500 Å2
Dissociation energy (ΔGdiss): 3 kcal/mol
Dissociation entropy (TΔSdiss): 15 kcal/mol
Interface energy (ΔGint): -88 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, C
Length: 402 amino acids
Theoretical weight: 48.25 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9QX73 (Residues: 71-463; Coverage: 80%)
  • Best match: Q9QX73-2 (Residues: 10-411)
Gene name: Arhgef9
Pfam:
InterPro:
CATH:
SCOP:

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Chains: B, D
Length: 194 amino acids
Theoretical weight: 21.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P60953 (Residues: 1-191; Coverage: 100%)
Gene name: CDC42
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: G proteins

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