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X-ray crystal structure analysis of bovine spleen cathepsin B-CA073 complex

X-ray diffraction
2.3Å resolution
PDB entry 2dc6 coloured by chain, front view.
PDB entry 2dc6 coloured by chain, side view.
PDB entry 2dc6 coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cathepsin B
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Multimeric state: monomeric
Accessible surface area: 10801.31 Å2
Buried surface area: 1153.2 Å2
Dissociation area: 128.47 Å2
Dissociation energy (ΔGdiss): 0.75 kcal/mol
Dissociation entropy (TΔSdiss): 0.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139698

Macromolecules

Cathepsin B
Chain: A
Length: 256 amino acids
Theoretical weight: 27.92 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P07688 (Residues: 80-335; Coverage: 81%)
Gene name: CTSB
Pfam: Papain family cysteine protease
InterPro:
CATH: Cysteine proteinases
SCOP: Papain-like
Cathepsin B in PDB entry 2dc6, assembly 1, front view.
Cathepsin B in PDB entry 2dc6, assembly 1, side view.
Cathepsin B in PDB entry 2dc6, assembly 1, top view.
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