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Crystal structure of mouse glutathione S-transferase, mu7 (GSTM7) at 1.6 A resolution

Source organism: Mus musculus
Biochemical function: glutathione binding
Biological process: cellular oxidant detoxification
Cellular component: intercellular bridge

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EC 2.5.1.18: Glutathione transferase

Reaction catalysed:
RX + glutathione = HX + R-S-glutathione
Systematic name:
RX:glutathione R-transferase
Alternative Name(s):
  • Glutathione S-alkyl transferase
  • Glutathione S-alkyltransferase
  • Glutathione S-aralkyltransferase
  • Glutathione S-aryltransferase
  • Glutathione S-transferase
  • S-(hydroxyalkyl)glutathione lyase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00043
Domain description: Glutathione S-transferase, C-terminal domain
Occurring in:
  1. Glutathione S-transferase Mu 7
The deposited structure of PDB entry 2dc5 contains 2 copies of Pfam domain PF00043 (Glutathione S-transferase, C-terminal domain) in Glutathione S-transferase Mu 7. Showing 1 copy in chain A.

PF02798
Domain description: Glutathione S-transferase, N-terminal domain
Occurring in:
  1. Glutathione S-transferase Mu 7
The deposited structure of PDB entry 2dc5 contains 2 copies of Pfam domain PF02798 (Glutathione S-transferase, N-terminal domain) in Glutathione S-transferase Mu 7. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003081
Domain description: Glutathione S-transferase, Mu class
Occurring in:
  1. Glutathione S-transferase Mu 7
IPR004045
Domain description: Glutathione S-transferase, N-terminal
Occurring in:
  1. Glutathione S-transferase Mu 7
IPR004046
Domain description: Glutathione S-transferase, C-terminal
Occurring in:
  1. Glutathione S-transferase Mu 7
IPR010987
Domain description: Glutathione S-transferase, C-terminal-like
Occurring in:
  1. Glutathione S-transferase Mu 7
IPR036282
Domain description: Glutathione S-transferase, C-terminal domain superfamily
Occurring in:
  1. Glutathione S-transferase Mu 7
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. Glutathione S-transferase Mu 7

Structure domains

CATH CATH domains
3.40.30.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Glutaredoxin
Homology: Glutaredoxin
Occurring in:
  1. Glutathione S-transferase Mu 7
The deposited structure of PDB entry 2dc5 contains 2 copies of CATH domain 3.40.30.10 (Glutaredoxin) in Glutathione S-transferase Mu 7. Showing 1 copy in chain A.
1.20.1050.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
Homology: Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
Occurring in:
  1. Glutathione S-transferase Mu 7
The deposited structure of PDB entry 2dc5 contains 2 copies of CATH domain 1.20.1050.10 (Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2) in Glutathione S-transferase Mu 7. Showing 1 copy in chain A.

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