Function and Biology

Crystal structure of Glu-tRNA(Gln) amidotransferase in the complex with tRNA(Gln)

Source organism: Methanothermobacter thermautotrophicus
Biochemical function: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
Biological process: translation
Cellular component: cytoplasm

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02637
Domain description: GatB domain
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
The deposited structure of PDB entry 2d6f contains 2 copies of Pfam domain PF02637 (GatB domain) in Glutamyl-tRNA(Gln) amidotransferase subunit E. Showing 1 copy in chain F [auth D].

PF02938
Domain description: GAD domain
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
The deposited structure of PDB entry 2d6f contains 2 copies of Pfam domain PF02938 (GAD domain) in Glutamyl-tRNA(Gln) amidotransferase subunit E. Showing 1 copy in chain F [auth D].

PF02934
Domain description: GatB/GatE catalytic domain
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
The deposited structure of PDB entry 2d6f contains 2 copies of Pfam domain PF02934 (GatB/GatE catalytic domain) in Glutamyl-tRNA(Gln) amidotransferase subunit E. Showing 1 copy in chain F [auth D].

PF17763
Domain description: Glutaminase/Asparaginase C-terminal domain
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
The deposited structure of PDB entry 2d6f contains 2 copies of Pfam domain PF17763 (Glutaminase/Asparaginase C-terminal domain) in Glutamyl-tRNA(Gln) amidotransferase subunit D. Showing 1 copy in chain C [auth A].

PF00710
Domain description: Asparaginase, N-terminal
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
The deposited structure of PDB entry 2d6f contains 2 copies of Pfam domain PF00710 (Asparaginase, N-terminal) in Glutamyl-tRNA(Gln) amidotransferase subunit D. Showing 1 copy in chain C [auth A].

PF18195
Domain description: GatD N-terminal domain
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
The deposited structure of PDB entry 2d6f contains 2 copies of Pfam domain PF18195 (GatD N-terminal domain) in Glutamyl-tRNA(Gln) amidotransferase subunit D. Showing 1 copy in chain C [auth A].

Rfam RNA family (Rfam)
RF00005
Domain description: tRNA
Occurring in:
  1. tRNA
The deposited structure of PDB entry 2d6f contains 2 copies of Rfam domain RF00005 (tRNA) in tRNA. Showing 1 copy in chain B [auth F].

InterPro InterPro annotations
IPR006034
Domain description: Asparaginase/glutaminase-like
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
IPR011878
Domain description: Glutamyl-tRNA(Gln) amidotransferase subunit D
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
IPR004115
Domain description: GAD-like domain superfamily
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
IPR037222
Domain description: GatD, N-terminal superfamily
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
IPR023168
Domain description: Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
IPR018027
Domain description: Asn/Gln amidotransferase
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
IPR003789
Domain description: Aspartyl/glutamyl-tRNA amidotransferase subunit B-like
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
IPR042114
Domain description: Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 1
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
IPR029351
Domain description: GAD domain
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
IPR017958
Domain description: Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
IPR006075
Domain description: Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
IPR017959
Domain description: Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
IPR014746
Domain description: Glutamine synthetase/guanido kinase, catalytic domain
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
IPR004414
Domain description: Glutamyl-tRNA(Gln) amidotransferase subunit E
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
IPR040919
Domain description: Asparaginase/glutaminase, C-terminal
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
IPR027473
Domain description: L-asparaginase, C-terminal
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
IPR027475
Domain description: Asparaginase/glutaminase, active site 2
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
IPR020827
Domain description: Asparaginase/glutaminase, active site 1
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
IPR027474
Domain description: L-asparaginase, N-terminal
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
IPR006033
Domain description: Type I L-asparaginase family
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
IPR037152
Domain description: L-asparaginase, N-terminal domain superfamily
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
IPR036152
Domain description: Asparaginase/glutaminase-like superfamily
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
IPR040918
Domain description: GatD, N-terminal
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D

Structure domains

CATH CATH domains
3.30.1360.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Gyrase A; domain 2
Homology: GAD-like domain
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
The deposited structure of PDB entry 2d6f contains 2 copies of CATH domain 3.30.1360.30 (Gyrase A; domain 2) in Glutamyl-tRNA(Gln) amidotransferase subunit E. Showing 1 copy in chain F [auth D].
3.40.50.40
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
The deposited structure of PDB entry 2d6f contains 2 copies of CATH domain 3.40.50.40 (Rossmann fold) in Glutamyl-tRNA(Gln) amidotransferase subunit D. Showing 1 copy in chain C [auth A].
3.40.50.1170
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: L-asparaginase, N-terminal domain
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
The deposited structure of PDB entry 2d6f contains 2 copies of CATH domain 3.40.50.1170 (Rossmann fold) in Glutamyl-tRNA(Gln) amidotransferase subunit D. Showing 1 copy in chain C [auth A].
2.30.30.520
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: SH3 type barrels.
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
The deposited structure of PDB entry 2d6f contains 2 copies of CATH domain 2.30.30.520 (SH3 type barrels.) in Glutamyl-tRNA(Gln) amidotransferase subunit D. Showing 1 copy in chain C [auth A].
1.10.150.380
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: GatB domain, N-terminal subdomain
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
The deposited structure of PDB entry 2d6f contains 1 copy of CATH domain 1.10.150.380 (DNA polymerase; domain 1) in Glutamyl-tRNA(Gln) amidotransferase subunit E. Showing 1 copy in chain E [auth C].
SCOP SCOP annotations
143812
Class: Alpha and beta proteins (a+b)
Fold: Glutamine synthetase/guanido kinase
Superfamily: Glutamine synthetase/guanido kinase
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
The deposited structure of PDB entry 2d6f contains 2 copies of SCOP domain 143812 (GatB/GatE catalytic domain-like) in Glutamyl-tRNA(Gln) amidotransferase subunit E. Showing 1 copy in chain F [auth D].
140757
Class: All alpha proteins
Fold: GatB/YqeY motif
Superfamily: GatB/YqeY motif
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
The deposited structure of PDB entry 2d6f contains 2 copies of SCOP domain 140757 (GatB/GatE C-terminal domain-like) in Glutamyl-tRNA(Gln) amidotransferase subunit E. Showing 1 copy in chain F [auth D].
55262
Class: Alpha and beta proteins (a+b)
Fold: DCoH-like
Superfamily: GAD domain-like
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit E
The deposited structure of PDB entry 2d6f contains 2 copies of SCOP domain 55262 (GAD domain) in Glutamyl-tRNA(Gln) amidotransferase subunit E. Showing 1 copy in chain F [auth D].
53775
Class: Alpha and beta proteins (a/b)
Fold: Glutaminase/Asparaginase
Superfamily: Glutaminase/Asparaginase
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
The deposited structure of PDB entry 2d6f contains 2 copies of SCOP domain 53775 (Glutaminase/Asparaginase) in Glutamyl-tRNA(Gln) amidotransferase subunit D. Showing 1 copy in chain C [auth A].
141301
Class: All beta proteins
Fold: Sm-like fold
Superfamily: GatD N-terminal domain-like
Occurring in:
  1. Glutamyl-tRNA(Gln) amidotransferase subunit D
The deposited structure of PDB entry 2d6f contains 2 copies of SCOP domain 141301 (GatD N-terminal domain-like) in Glutamyl-tRNA(Gln) amidotransferase subunit D. Showing 1 copy in chain C [auth A].