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Crystal structure of the Sec-PH domain of the human neurofibromatosis type 1 protein

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13716
Domain description: Divergent CRAL/TRIO domain
Occurring in:
  1. Neurofibromin
The deposited structure of PDB entry 2d4q contains 2 copies of Pfam domain PF13716 (Divergent CRAL/TRIO domain) in Neurofibromin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001251
Domain description: CRAL-TRIO lipid binding domain
Occurring in:
  1. Neurofibromin
IPR036865
Domain description: CRAL-TRIO lipid binding domain superfamily
Occurring in:
  1. Neurofibromin
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Neurofibromin
IPR039360
Domain description: Ras GTPase-activating protein
Occurring in:
  1. Neurofibromin

Structure domains

CATH CATH domains
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Neurofibromin
The deposited structure of PDB entry 2d4q contains 2 copies of CATH domain 2.30.29.30 (PH-domain like) in Neurofibromin. Showing 1 copy in chain A.
3.40.525.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Phosphatidylinositol Transfer Protein Sec14p
Homology: CRAL-TRIO lipid binding domain
Occurring in:
  1. Neurofibromin
The deposited structure of PDB entry 2d4q contains 2 copies of CATH domain 3.40.525.10 (Phosphatidylinositol Transfer Protein Sec14p) in Neurofibromin. Showing 1 copy in chain A.

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