PDBe 2csn

X-ray diffraction
2.5Å resolution

BINARY COMPLEX OF CASEIN KINASE-1 WITH CKI7

Released:
Source organism: Schizosaccharomyces pombe
Primary publication:
Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors.
Proc. Natl. Acad. Sci. U.S.A. 93 6308-13 (1996)
PMID: 8692811

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 34.25 KDa
Source organism: Schizosaccharomyces pombe
Expression system: Escherichia coli
UniProt:
  • Canonical: P40233 (Residues: 2-298; Coverage: 67%)
Gene names: SPBC1347.06c, cki1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P3221
Unit cell:
a: 79.1Å b: 79.1Å c: 120.04Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.178 0.178 not available
Expression system: Escherichia coli